Table 1.

Diagnostic tools for the conformation of an occupational isocyanate associated asthma [22], modified.

Diagnostic Approach	Result
Medical examination
Occupational anamnesis, exposure on the job	Clinical verification of the asthmatic disease Confirmation of isocyanate exposure: characterization of the chemical substances Specification of the grade of exposure
Physiological tests:
Metacholine provocation test Spirometry PERFs (peak expiratory flow rate)	Confirmation of the diagnose “asthma” and documentation of the occupational causation
SIC (specific inhalation challenge)	“Diagnostic reference standard”, characterization of the specific substance
Immunological investigations
Isocyanate specific IgE	Strong indicator for isocyanate induced asthma, not very sensitive
Isocyanate specific IgG	Conformation of exposure towards isocyanate