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HLA-A, HLA-B and HLA-C cytoplasmic tail sequences. Y320, A324 and D327 are required for Nef-mediated AP-1 recruitment and MHC-I down-modulation of HLA-A and HLA-B cytoplasmic tails. Y320 and D327 are absent in HLA-C cytoplasmic tail sequences, which are not down-modulated by Nef. HLA-C is internalized more rapidly than HLA-A and HLA-B because of a di-hydrophobic motif (L336I337) present in the cytoplasmic tail that is regulated by phosphorylation of an adjacent residue (S335).
