Figure 2.

Comparison of response magnitudes of CD4⁺ and CD8⁺ T cells to Epstein–Barr virus (EBV) proteins. Responses to EBV lytic (BZLF1) and latent (EBNA1, EBNA3A-C, LMP2) overlapping peptide pools were analysed for both CD4⁺ and CD8⁺ T cells, respectively. Each dot represents the percentages of responsive CD4⁺ or CD8⁺ T cells for an individual. The median percentages of responsive T cells in 20 long-term carriers for each peptide pool were shown as a horizontal line. There was no significant difference among the response magnitudes towards six EBV overlapping peptide pools for either CD4⁺ or CD8⁺ T cells (one-way anova test, P-value > 0.05). There was significant difference between CD4⁺ and CD8⁺ T-cell response magnitudes towards the same overlapping peptide pools (two-sided Wilcoxon's signed-rank test, P-value < 0.05).