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. Author manuscript; available in PMC: 2011 Oct 17.
Published in final edited form as: Nat Rev Drug Discov. 2010 Oct;9(10):790–803. doi: 10.1038/nrd3253

Figure 1. Chemical structures of microtubule binding agents according to binding domains.

Figure 1

Figure 1

This figure shows the extreme chemical diversity as well as the complexity of many of these agents. The complex structure of certain natural compounds explains the difficulty encountered by chemists to perform total synthesis of these molecules.