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. Author manuscript; available in PMC: 2012 Apr 15.
Published in final edited form as: Cancer Res. 2011 Oct 15;71(20):6438–6449. doi: 10.1158/0008-5472.CAN-11-1645

Figure 3. AOM/DSS induction of CRC in wt and Akd+/− mice.

Figure 3

(A) Macroscopic view of representative X-gal stained mouse colons (129SVcc background) at end of protocol (distal end at top; bar 1cm). (B) Percentage of mice that developed tumors. (C) Mean number of tumors observed from wt (n=12) and Akd+/− (n=7) mice in a 129SVcc background and wt (n=6) and Akd+/− (n=6) mice in a 129SVcc/CD1 background. (D-I) H&E staining of colons and tumors from wt and Akd+/− treated mice. wt: (D) normal colon, (E) adenoma with severe dysplasia and (F) intramucosal carcinoma. Akd+/−: (G) intramucosal carcinoma with mucus production, (H) invasive adenocarcinoma and (I) vessel invasion. Black arrowheads mark sites of invasion. (D-H) shown at x2.5 magnification; bar 250μm and (I) at x20 magnification; bar 50μm.