Table 2. Histopathology of wt and Akd+/− colorectal tumors.
Tumors from all wt (n=12) and all Akd+/− (n=7) mice (129SVcc background) were subjected to histopathological analysis. Colons were examined along the entire distal-proximal axis. VI = vessel invasion found in one tumor.
| Mouse | Tumors | Tumors Analyzed |
Adenomas | Intramucosal Carcinomas |
Invasive Carcinomas |
|---|---|---|---|---|---|
|
| |||||
| wt_1 | 5 | 5 | - | 5 | - |
| wt_2 | 1 | 1 | - | 1 | - |
| wt_3 | 2 | 2 | - | 2 | - |
| wt_4 | 3 | 3 | 1 | 2 | - |
| wt_5 | 3 | 3 | - | 3 | - |
| wt_6 | - | - | n/a | n/a | n/a |
| wt_7 | - | - | n/a | n/a | n/a |
| wt_8 | - | - | n/a | n/a | n/a |
| wt_9 | - | - | n/a | n/a | n/a |
| wt_10 | - | - | n/a | n/a | n/a |
| wt_11 | 6 | 6 | 2 | 4 | - |
| wt_12 | 3 | 3 | - | 3 | - |
|
| |||||
| Total | 23 | 23 | 3 (13%) | 20 (87%) | - |
|
| |||||
| Akd+/−_1 | 10 | 3 | - | 3 | - |
| Akd+/−_2 | 9 | 3 | - | 3VI | - |
| Akd+/−_3 | 9 | 3 | - | 2 | 1 |
| Akd+/−_4 | 3 | 3 | - | 3 | - |
| Akd+/−_5 | 5 | 3 | - | 3 | - |
| Akd+/−_6 | 7 | 4 | - | 4 | - |
| Akd+/−_7 | 10 | 5 | - | 5 | - |
|
| |||||
| Total | 53 | 24 | - | 23 (96%) | 1 (4%) |