Figure 3. Both HRV14 and T cells enhance CXCL10, but only T cells enhance CXCL8 and IL-6 protein secretion by HNEC.

HNEC were either not infected (C) or exposed apically to HRV14 alone (HRV), and co-cultured or not with activated T cells (T cells). The production of CXCL10 (A), CXCL8 (B) and IL-6 (C) was measured in apical and basolateral culture supernatants. Shown are the boxplots with the 25^th, 50^th (median), 75^th percentiles, the mean (open square), the maximum and the minimum values. *p<0.05. In co-cultures experiments, the amounts of cytokines/chemokines released by epithelial cells in the basolateral compartments were determined by subtracting the amounts of cytokines/chemokines measured in the culture media of activated T cells cultures alone (undetectable for CXCL10, 0.034 ng/ml for CXCL8, 10.6 pg/ml for IL-6, median).