Table 1. Summary of the subcellular localization of the missense mutants described in this study.
Mutant | Domain | Experimental localization* |
Wild type | None | Predominantly PM |
L32R | Orphan Domain | ER |
V49F | Orphan Domain | ER |
C53R | Orphan Domain | ER |
V125D | Orphan Domain | ER |
W149C | Orphan Domain | Predominantly PM |
A160D | Orphan Domain | ER |
P165L | Orphan Domain | ER |
D264N | Orphan Domain | Predominantly PM |
I271N | Orphan Domain | ER |
A308D | Orphan Domain | ER |
V311G | Orphan Domain | Predominantly PM |
C363Y | ZP-N Domain | ER |
C382G | ZP-N Domain | Predominantly PM |
C382W | ZP-N Domain | ER |
F403S | ZP-N Domain | Predominantly PM |
S407N | ZP-N Domain | Predominantly PM |
C412S | ZP-N Domain | Predominantly PM |
G413V | ZP-N Domain | Predominantly PM |
N423S | ZP-N Domain | Predominantly PM |
A425G | ZP-C Domain | Predominantly PM |
R437W | ZP-N Domain | Predominantly PM |
Q476H | ZP-C Domain | Predominantly PM |
V504M | ZP-C Domain | Predominantly PM |
R571H | ZP-C Domain | Predominantly PM |
S615L | Intracellular Domain | Predominantly PM |
*Subcellular localization have been established by confocal microscopy and/or Endo H analysis.