Figure 4. In primary cultures of differentiated subcutaneous (a) and omental (b) pre-adipocytes, Dex decreases lipogenesis in the absence of insulin.

Insulin stimulates lipogenesis in both subcutaneous and omental cells (a and b). In omental cells only, Dex impairs the ability of insulin to stimulate lipogenesis (b). (Activity data are expressed relative to untreated cells (no insulin, no Dex) and are the mean±se of n = 3–5 experiments. Control cells are shown in the white bars, low dose dexamethasone treatment (5 nM) grey bars, high dose (500 nM) black bars, * p<0.05 vs. Ctrl and § p<0.05 om, 5 nM insulin vs. sc, 5 nM insulin).