Table 5.
Resistance of clinical isolates to antimicrobial agentsd
| Antimicrobial agent | 1993 study (n = 12)a |
2001 study (n = 16)b |
CHIMED study, 2003-2004 (n = 18)c |
|||
|---|---|---|---|---|---|---|
| MIC50 | MIC90 | Disk (μg/ml) | % sensitivity | MIC50 | MIC90 | |
| Ciprofloxacin | 2 | 8 | 2 | 100 | ≤1 | 4 |
| Clarithromycin | ≤0.25 | ≤0.25 | 3 | 100 | ≤2 | ≤2 |
| Rifabutin | ≤0.03 | ≤0.03 | NT | NT | ≤0.2 | ≤0.2 |
| Rifampin | 0.5 | 1 | 1 | 94 | 0.2 | 1 |
| Amikacin | 4 | 8 | 2 | 100 | 10 | 20 |
| Ethionamide | R* | R* | 5 | 0 | NT | NT |
| Streptomycin | NT | NT | 10 | 100 | 10 | 20 |
| Ethambutol | R* | R* | 5 | 0 | >20 | >20 |
| Isoniazid | 8 | >32 | 0.2 | 0 | ≥20 | ≥20 |
| Clofazimine | 2 | 2 | NT | NT | ≤0.5 | ≤0.5 |
| Prothionamide | NT | NT | NT | NT | 5 | 20 |
| Cycloserine | NT | NT | NT | NT | 50 | >50 |
a
Data from reference 9. The method applied was a microtiter array with Middlebrook 7H9 broth plus hemin. MICs are in μg/ml.
b
Data from reference 126. The method applied was a disk elution method on Middlebrook 7H10 agar with hemin.
c
The method applied was an agar dilution method on Middlebrook 7H10 medium with a hemin source. MICs are in μg/ml.
d
R*, tested but not active; NT, not tested.