Table 4.
Cellular genes significantly downregulated upon HCMV infection
| Gene | Relative downregulation at time (h) postinfectiona |
||||
|---|---|---|---|---|---|
| M 96 vs WT 48 | M 96 vs R 48 | M 96 vs WT 96 | M 96 vs R 96 | M 96 vs R 168 | |
| β-Actin | 6.67 | 5.56 | 10.00 | 6.67 | 14.29 |
| Lamin A | 4.76 | 4.00 | 6.67 | 6.67 | 6.67 |
| Cyclin D1 | 3.85 | 3.57 | 4.17 | 4.00 | 3.85 |
| TIMP3 | 4.35 | 4.35 | 4.00 | 4.00 | 3.85 |
| c-FOS | 3.57 | 3.57 | 3.70 | 3.70 | 3.70 |
| JAK1 | 3.23 | 2.13 | 3.57 | 2.94 | 3.57 |
| SHC | 2.33 | 3.03 | |||
| SP1 | 2.56 | 2.27 | 2.50 | 2.94 | |
| NEDD8 | 2.56 | 2.86 | |||
| PKCa | 2.63 | 2.33 | 2.63 | 2.27 | 2.70 |
| STAT2 | 2.27 | 2.27 | 2.63 | 2.44 | 2.44 |
| ROC1 | 2.44 | 2.27 | |||
| p50 | 2.27 | 2.17 | |||
| SHP2 | 2.17 | ||||
| PLCγ | 2.13 | ||||
| c-JUN | 2.00 | 2.00 | 2.00 | ||
| CDK4 | 2.00 | ||||
| DP1 | 2.08 | 2.00 | |||
| CAS | 2.17 | ||||
| DSH | 2.33 | 2.04 | 2.22 | ||
a
Significant changes (fold) between the indicated samples are shown. M, mock; WT, wild type; R, Q548R IE2. The time (number of hours) postinfection is the time at which the sample was harvested; e.g., M 96 vs WT 48 indicates the ratio of mock 96 h p.i. to WT 48 h p.i. for a given gene. Blank cells indicate that the change did not meet the criteria for significance.