Fig. 9.

(A) Topological model for 2B association with membranes. (B) Turn-inducing propensity at the interhelical region of the viroporin 2B helical hairpin according to the scale of Monné and coworkers (39). The five amino acid residues interconnecting HR1 and HR2 are shown flanked by the putative last two residues from the HR1 helix and the putative first two residues from HR2. All residues connecting HR1 and HR2 are turn inducers (normalized turn potential, >1). The residues are highlighted according to their turn potential: black for a potential lower than 1 (Ile54), dark gray for a potential between 1 and 2 (Thr55, Tyr58, and Thr61), and light gray for a potential above 2 (Arg56, Asn57, Glu59, and Asp60).