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. 2011 Nov;85(21):11146–11158. doi: 10.1128/JVI.05499-11

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Fig. 5. — Analysis of the IRG1-containing cluster of genes identified using Biolayout Express 3D software. (A) EasyGO analysis shows a significant enrichment of genes involved in apoptosis and the regulation of apoptosis. (B) IPA analysis also reveals cell death to be a highly featured function of the genes in this cluster. (C) A subcluster identified using the Expander program is seen to be highly overrepresented (more than 4-fold) by genes which contain a binding site for the transcription factor OCT1 (octamer-binding transcription factor 1). Genes with binding sites for DBP (albumin D box-binding protein) also are seen to be enriched. DBP is thought to be involved in the modulation of circadian rhythms.