Table 2.
Candidate genes for Marek's disease resistance
| Gene | Description | Analysisa | Fold change | Tissueb | Comment | Accession no. |
|
|---|---|---|---|---|---|---|---|
| GenBank | Ensembl | ||||||
| IgG-H | IgG H-chain (HC36) D-J-C | D | 10–22 | S and T | X07174 | ||
| AMIGO2 | Adhesion molecule with Ig-like domain 2 | D | 5 | S | XM_416052 | ENSGALG00000009739 | |
| MMP13 | Matrix metalloproteinase-13 | D | 3 | S | XM_001235209 | ENSGALG00000017183 | |
| CLEC3B | Tetranectin | D | 3 | S | NM_204666 | ENSGALG00000011883 | |
| AVD | Avidin precursor | D | 38 | S | Between 2 QTL | NM_205320 | ENSGALG00000023622 |
| IFNA | Alpha interferon | D | 28 | T | Between 2 QTL | NM_205427 | ENSGALG00000013245 |
| MMP9 | Matrix metalloproteinase-9 | D | 10 | T | NM_204667 | ENSGALG00000006992 | |
| IL-18 | Interleukin-18 precursor | D | 5 | S | NM_204608 | ENSGALG00000007874 | |
| TLR15 | Toll-like receptor 15 | D | 3 | S | NM_001037835 | ENSGALG00000008166 | |
| MX1 | Interferon-induced GTP-binding protein Mx. | D | 3–4 | S | Under QTL (MD2) | NM_204609 | ENSGALG00000016142 |
| IL-6 | Mature chil-6 | D | 2–4 | S | Near MD3 | NM_204628 | ENSGALG00000010915 |
| FN1 | Fibronectin | D | 3 | S | Under QTL (MD10) | XM_421868 | ENSGALG00000003578 |
| IRG1 | Immunoresponsive protein 1 | D | 14 | S | Quite near MD2 | NM_001030821 | ENSGALG00000016919 |
| DDT | d-Dopachrome tautomerase | I | 79–110 | S and T | Under QTL (MD24) | NM_001030667 | ENSGALG00000006350 |
| DNAJC3 | DnaJ homolog subfamily C member 3 | I | 14–27 | S and T | Under QTL (MD2) | NM_001008437 | ENSGALG00000016894 |
| SFTPA2 | Lung lectin precursor | I | 17 | S | Under QTL (MD22) | NM_001039166 | ENSGALG00000002496 |
| GNG12 | Guanine nucleotide-binding protein | I | 9 | S | Under QTL (MD23) | XM_001234702 | ENSGALG00000020596 |
a
D, differential response between the lines upon infection; I, inherently different between control birds of the resistant and susceptible lines.
b
S, spleen; T, thymus.