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. 2011 Nov;85(21):11069–11078. doi: 10.1128/JVI.05318-11

Fig. 3.

Fig. 3.

Expression of chemokine receptor genes in hMSCs and chemokine genes in the brains of prion-infected mice. (A) Expression of chemokine and growth factor receptor genes in hMSCs stimulated with brain extracts of prion-infected mice. The hMSCs were incubated for a day in DMEM containing 1% brain extracts of prion-infected mice prepared at 120 dpi or of age-matched mock-infected mice. Expression of the mRNA of the indicated genes was then analyzed using qRT-PCR. The graph shows the fold increase in gene expression in hMSCs incubated with brain extracts of prion-infected mice compared to hMSCs incubated with brain extracts of mock-infected mice. The results of two independent experiments are shown. (B) Expression of chemokine genes in the brains of prion-infected mice. The graph shows the fold increases in gene expression in the brains of prion-infected mice at 120 dpi compared to the brains of age-matched mock-infected mice. Means and SDs (n = 3) of the fold increase are shown.