Fig. 7.

Bcl-6 expression correlates with EBV latency program. The indicated cell lines were subjected to immunoblotting to detect expression of Bcl-6, a marker for germinal center B cells that is highly expressed in BL cells that maintain latency I but is very low or undetectable in BL cells and LCLs that support latency III. The lack of Bcl-6 expression in the BL lines Oku and Sal, which maintain a Wp-restricted latency, suggests that these cells are otherwise programmed to support latency III, consistent with the EBV latency-associated protein expression pattern established within superinfected Sal cells (see Fig. 6A). The faint bands in the Ak-LCL lane are due to spillover from Ak-BL in the adjacent lane.