Fig. 7.
In vivo evaluation of the anti-HCV effect of GRFT. Chimeric mice were treated daily with GRFTWT (green) or GRFTMUT (orange) at a dose of 5 mg/kg of body weight. Three days after the first dose, the mice were challenged with serum-derived HCV of strain H77 (genotype 1a). Each symbol represents the value for an individual mouse, and the short horizontal solid line and broken line represent the geometric mean viral load of GRFTMUT- and GRFTWT-treated mice, respectively. LOD, limit of detection (750 IU/ml).