Table 1.
MICs of amphotericin B for QC and reference strains as determined in eight laboratories at 48 h
| QC or laboratory control isolate | QC MIC range (mode),a μg/ml | % CLSI MICs within range | MIC range (mode),a μg/ml, determined by laboratory: |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | |||
| Paecilomyces variotii ATCC MYA-3630 | 1-4 (2) | 100 | ND | 1-2 (2) | 1-2 (2) | ND | 1-4 (2) | ND | ND | 1-2 (2) |
| Aspergillus flavus ATCC 204304 | 0.5-4 (NA) | 100 | 0.5-1 (0.5) | ND | ND | 0.25-1 (1)b | ND | ND | 0.5-2 (2) | ND |
| Aspergillus fumigatus NCPF 7097 | NA | NA | ND | ND | ND | ND | ND | 0.5-2 (1) | ND | ND |
| Aspergillus fumigatus NCPF 7100 | NA | NA | ND | ND | ND | ND | ND | 1-2 (1) | ND | ND |
| Candida parapsilosis ATCC 22019 | 0.5-4 (2) | 91.7 | 0.5 (0.5) | 1-2 (2) | 0.5-4 (1) | 0.5-2 (1) | ND | 0.5-4 (1) | 0.5-1 (1) | ND |
| Candida krusei ATCC 6258 | 1-4 (2) | 100 | 1 (1) | 1-4 (2) | 0.5-2 (1) | 1-2 (2) | 1-4 (2) | 1-2 (1) | 1-2 (2) | 1-2 (2) |
a
MICs were determined as recommended by the CLSI M38-A2 document (8). ND, Not determined. NA, QC MIC limits are not available, but the A. flavus strain is listed in the CLSI M38-A2 document as a reference isolate.
b
MICs were outside the range for reference isolate A. flavus ATCC 204304 (2%).