Table 4.
Percentages of isolates of six Aspergillus spp. above the amphotericin B WT distribution from eight laboratories as determined by CLSI M38-A2 and EUCAST broth microdilution methods at 48 h
| Species | ECV, μg/ml (% of isolates above each WT distribution)a |
||
|---|---|---|---|
| ≥95% | ≥97.5% | >99% | |
| A. fumigatus | 2 (0.3)/0.5 (7.6)/2 (0.3) | 2 (0.3)/1 (1.2)/2 (0.3) | 4 (0.1)/1 (1.2)/4 (0.1) |
| A. flavus | 2 (2.6)/2 (3.6)/2 (2.8) | 4 (0.3)/2 (3.6)/4 (0.3) | 4 (0.3)/2 (3.6)/4 (0.3) |
| A. nidulans | 4 (1.1)/2 (11.6)/4 (2.4) | 4 (1.1)/4 (5.8)/4 (2.4) | 4 (1.1)/4 (5.8)/8 (1.2) |
| A. niger | 2 (0)/0.5 (0)/2 (0) | 2 (0)/0.5 (0)/2 (0) | 4 (0)/0.5 (0)/4 (0) |
| A. terreus | 4 (3.9)/4 (5.3)/4 (4.3) | 4 (3.9)/4 (5.3)/4 (4.3) | 8 (0.2)/4 (5.3)/4 (0.7) |
| A. versicolor | 2 (8.1)/2 (4.5)/2 (4.5) | 2 (8.1)/4 (0)/2 (7.6) | 2 (8.1)/4 (0)/4 (0.6) |
a
Calculated ECVs comprising ≥95, ≥97.5, or ≥99% of the statistically modeled population, determined using CLSI/EUCAST/combined CLSI and EUCAST data.