Table 1.
Antibiotic profiles of compounds 1 and 2
| Test agent | MIC (μg/ml) |
CC50 (μg/ml) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| E. faecalis ATCC 29212 | S. aureus ATCC 29213 | S. pneumoniae ATCC 49619 | E. coli ATCC 25922 | K. pneumoniae ATCC 700603 | P. aeruginosa ATCC 27853 | K562 | HEK293 | HepG2 | |
| GE2270 A | 0.5 | 0.5 | 0.5 | >64 | >64 | >64 | >128 | >128 | >128 |
| Compound 1 | 0.06 | 0.06 | 4 | >32 | >32 | >32 | 6.27 | 53.68 | 46.94 |
| Compound 2 | 0.25 | 0.125 | 1 | >32 | >32 | >32 | 8.85 | 29.63 | 42.6 |
| Tetracycline | 32 | 0.5 | 0.25 | 1 | 16 | 16 | 61.1 | >128 | >128 |
| Vancomycin | 4 | 0.5 | 0.125 | ND | ND | ND | >64 | >64 | >64 |
| Linezolid | 2 | 2 | 1 | ND | ND | ND | >128 | >128 | >128 |
| Daptomycin | 4 | 0.5 | ≤0.25 | ND | ND | ND | >128 | >128 | >128 |
| Puromycin | NDa | ND | ND | ND | ND | ND | 0.3 | 0.29 | 0.94 |
| Azithromycin | 1 | 1 | 0.06 | 4 | ND | >16 | 96.7 | 61.1 | 21.7 |
a
ND, not determined.