Table 1.
Test agent | MIC (μg/ml) |
CC50 (μg/ml) |
|||||||
---|---|---|---|---|---|---|---|---|---|
E. faecalis ATCC 29212 | S. aureus ATCC 29213 | S. pneumoniae ATCC 49619 | E. coli ATCC 25922 | K. pneumoniae ATCC 700603 | P. aeruginosa ATCC 27853 | K562 | HEK293 | HepG2 | |
GE2270 A | 0.5 | 0.5 | 0.5 | >64 | >64 | >64 | >128 | >128 | >128 |
Compound 1 | 0.06 | 0.06 | 4 | >32 | >32 | >32 | 6.27 | 53.68 | 46.94 |
Compound 2 | 0.25 | 0.125 | 1 | >32 | >32 | >32 | 8.85 | 29.63 | 42.6 |
Tetracycline | 32 | 0.5 | 0.25 | 1 | 16 | 16 | 61.1 | >128 | >128 |
Vancomycin | 4 | 0.5 | 0.125 | ND | ND | ND | >64 | >64 | >64 |
Linezolid | 2 | 2 | 1 | ND | ND | ND | >128 | >128 | >128 |
Daptomycin | 4 | 0.5 | ≤0.25 | ND | ND | ND | >128 | >128 | >128 |
Puromycin | NDa | ND | ND | ND | ND | ND | 0.3 | 0.29 | 0.94 |
Azithromycin | 1 | 1 | 0.06 | 4 | ND | >16 | 96.7 | 61.1 | 21.7 |
ND, not determined.