Table 5.
In vivo efficacy of compounds 1 and 2 against experimental lethal E. faecalis and S. aureus infections in mice
| Species | Inoculum (CFU/mouse) | Test agent | MIC (μg/ml) | ED50 (mg/kg) (95% CI)a |
|---|---|---|---|---|
| E. faecalis | 1.0 × 108 | Compound 1 | 0.06 | <3.125 |
| Daptomycin | 8 | 2.01 (NC) | ||
| 1.5 × 108 | Compound 1 | 0.06 | 0.56 (NC) | |
| Compound 2 | ≤0.015 | <1.11 | ||
| Daptomycin | 8 | 2.88 (NC) | ||
| 1.1 × 108 | Compound 2 | ≤0.015 | 0.23 (NC) | |
| Daptomycin | 8 | 2.88 (NC) | ||
| S. aureus | 1.1 × 108 | Compound 1 | 0.125 | 5.22 (3.66–7.16) |
| Daptomycin | 1 | 0.36 (0.22–0.54) | ||
| 1.2 × 108 | Compound 2 | 0.25 | 4.32 (0.53–11.68) | |
| Daptomycin | 1 | <0.22 |
a
NC, not calculable.