Table 5.
Species | Inoculum (CFU/mouse) | Test agent | MIC (μg/ml) | ED50 (mg/kg) (95% CI)a |
---|---|---|---|---|
E. faecalis | 1.0 × 108 | Compound 1 | 0.06 | <3.125 |
Daptomycin | 8 | 2.01 (NC) | ||
1.5 × 108 | Compound 1 | 0.06 | 0.56 (NC) | |
Compound 2 | ≤0.015 | <1.11 | ||
Daptomycin | 8 | 2.88 (NC) | ||
1.1 × 108 | Compound 2 | ≤0.015 | 0.23 (NC) | |
Daptomycin | 8 | 2.88 (NC) | ||
S. aureus | 1.1 × 108 | Compound 1 | 0.125 | 5.22 (3.66–7.16) |
Daptomycin | 1 | 0.36 (0.22–0.54) | ||
1.2 × 108 | Compound 2 | 0.25 | 4.32 (0.53–11.68) | |
Daptomycin | 1 | <0.22 |
NC, not calculable.