Fig. 4.

RC-101 prevents adherence and survival of S. aureus on human nasal epithelia. Shown are growth curve data for adhered and wash fractions from human nasal epithelia cocultured with S. aureus in the presence and absence of RC-101. Nasal carriage strains include D20-7, D535-6, and D30. USA300 represents a clinical isolate. Limit of detection for the 3-h time point is nine (i.e., log₁₀ = 0.95) total CFU, while the limit of detection for 6- and 9-h time points equals 18 (i.e., log₁₀ = 1.26) total CFU. n ≥ 3 for all strains. Values are means ± SEM. * indicates the starting inoculum. #, P < 0.05; ##, P < 0.01; ###, P < 0.001. P values indicate statistical significance compared to vehicle-treated samples. For clarity of presentation, P values are shown for 9-h treatments only.