Fig. 1.
Evaluation of various doses of levofloxacin (Levo) in a pneumonic rat model of infection. Groups of 6 rats were exposed to a 12 LD50 of Y. pestis CO92 and administered levofloxacin at the indicated doses. Additionally, 9 rats were infected and received PBS instead of levofloxacin as a negative control. The duration of the drug treatment is indicated by the red bar. The animals in the levofloxacin-treated groups were rechallenged and monitored for lethality. P values indicate statistical significance.