Fig. 2.
Evaluation of dose-response effect of cethromycin in a pneumonic rat model of infection. Groups of 9 rats were exposed to a 25 LD50 of Y. pestis CO92 and administered cethromycin at the indicated doses. A negative control consisted of rats administered PBS instead of cethromycin (Cethro), and as a positive control rats received 20 mg/kg/day of levofloxacin (Levo) either orally or intraperitoneally. Drug treatments were administered for either 7 or 14 days, and administration lengths are indicated by red and blue bars. P values indicate statistical significance.