Fig. 6.
Evaluation of delayed administration of various doses of levofloxacin in a pneumonic rat model of infection. Groups of rats exposed to a 12 LD50 of Y. pestis CO92 and 24 to 48 h following Y. pestis infection were i.p. administered levofloxacin (Levo) at the indicated doses. As a negative control, 9 rats were infected and administered PBS. The solid black vertical line indicates rechallenging of the surviving animals. A group of 9 naïve rats was infected and served as rechallenge control. P values indicate statistical significance.