Table 1.
Ability of cethromycin to kill Y. pestis CO92 (24 LD50s) in the blood and spleens of ratsa
| Day | CFU/ml in: |
|||||
|---|---|---|---|---|---|---|
| Blood |
Spleen |
|||||
| Rat 1 | Rat 2 | Rat 3 | Rat 1 | Rat 2 | Rat 3 | |
| Control | ||||||
| Day 1 | 0 | 0 | 0 | |||
| Day 2 | 4.1 × 108 | 5.9 × 108 | 5.5 × 108 | 1.2 × 108 | 1.0 × 109 | 2.9 × 107 |
| Cethro | ||||||
| Day 1 | 0 | 0 | 0 | |||
| Day 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Day 3 | 0 | 0 | 0 | |||
| Day 4 | 0 | 0 | 0 | 0 | 0 | 0 |
| Day 5 | 0 | 0 | 0 | |||
| Day 6 | 0 | 0 | 0 | 0 | 0 | 0 |
| Day 7 | 0 | 0 | 0 | |||
a
Three control and cethromycin (Cethro)-treated and Y. pestis-infected rats were evaluated for either 2 or up to 7 days, respectively, for CFU in the blood. All of the control animals died by day 3. The spleens from Y. pestis-infected and cethromycin-treated and infected rats were examined for CFU on days 2, 4, and 6 postinfection.