Table 2.

Summary of pharmacokinetic parameters for peramivir and oseltamivir carboxylate in plasma

Drug	Animal	Route	Dose (mg/kg)	Mean ± SD for indicated parametera
				Cmax (μg/ml)b	Tmax (h)	AUC0-∞c (μg·h/ml)
Peramivir	Ferret	Intravenous	30	194 ± 56	NAd	89.1 ± 21.9
	Cynomolgus macaque			160 ± 23	NA	234 ± 45
Oseltamivir carboxylate	Ferret	Oral	30	4.38 ± 0.68	2.67 ± 1.15	23.7 ± 2.7
	Cynomolgus macaque			6.44 ± 3.18	3.0 ± 1.0	25.4 ± 2.0

^aMeans and SDs of data from three animals are shown.

^bC_max was calculated as the concentration at time zero for the intravenous dose.

^cAUC_0-∞, area under the concentration-time curve from 0 h to infinity.

^dNA, not applicable.