Table 2.

Multivariate analysis of the association of amino acid changes from the reference sequence HXB2 within the single regions of gp120 with the DM or R5 phenotype by ESTA

Region	Amino acid change	P value	Odds ratio	95% CI
C1	V84L	0.044	21.51	1.07–429.17
V1	N139T	0.021	0.01	0.00–0.50
	R166G	0.030	0.06	0.00–0.76
V2	V169K	0.031	0.13	0.02–0.83
	S195N	0.044	0.10	0.01–0.93
C2	T198A	0.030	118.91	1.59–8,884.67
	T232K	0.041	5.88	1.07–32.27
V3	R315K	<0.001	0.02	0.00–0.13
	K343A	0.015	45.06	2.07–978.01
C3	Q344K	0.017	0.06	0.00–0.61
	I360K	<0.001	64.68	7.02–595.54
	Q363K	0.031	8.25	1.21–56.25
V4	T413I	0.031	13.52	1.26–144.36
C4	S440K	0.022	32.15	1.64–630.01
	S446T	0.007	30.47	2.50–371.14
V5	E464S	0.001	105.60	6.03–1,848.61