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. 2011 Nov;55(11):5043–5053. doi: 10.1128/AAC.05009-11

Fig. 5.

Fig. 5.

DNA microarray showing upregulation of stress-induced genes by PMX 10070 and polymyxin B. E. coli genes upregulated >1.7-fold by PMX 10070 (8.75 μg/ml, 0.7× MIC) and polymyxin B (0.39 μg/ml, 1× MIC) treatment 20 and 60 min after exposure. (A) Upregulated genes in response to polymyxin B treatment for 20 min (a) and 60 min (b) and PMX 10070 treatment for 20 min (c) and 60 min (d). rpoS-regulated stress response genes are highlighted in red. (B) Upregulated stress response genes are regulated by rcs, marA-soxS, cpxAR-baeSR, kdp, and rpoS. (C) Most upregulated genes by exposure time (20 min and 60 min), treatment (polymyxin B and PMX 10070), and time and treatment belong to the rcs phosphorelay.