Table 1.

Parameter values for the model linking tedizolid exposure to killing of Staphylococcus aureus ATCC 33591

Parameter	Unit of measurement	Mean	Median	SD
Kg	h−1	1.300	0.884	0.879
Popmax	CFU/g	1.36 × 109	1.72 × 109	6.48 × 108
Kk-max	h−1	1.782	0.104	2.768
C50k	mg/liter	3.860	4.513	1.848
Hk	Unitless	8.056	7.895	0.431
WBCKillN	(CFU/g)/h	0.657	0.536	0.557
WBCKillN50	CFU/g	3.47 × 106	2.41 × 106	3.02 × 106
WBCKillNN	(CFU/g)/h	2.638	0.995	3.797
WBCKillNN50	CFU/g	1.58 × 106	1.80 × 104	3.22 × 106

K_g values represent the first-order growth rate constant; Popmax values represent the estimated maximal number of organisms in stationary phase; K_k-max values represent the first-order kill rate constant directly induced by tedizolid; C_50k values represent the tedizolid concentration at which kill rate is half maximal; H_k values represent the Hill constant; WBCKillN values represent the maximal kill rate induced by granulocytes in the granulocytopenic cohort; WBCKillN₅₀ values represent the organism load at which the system is half saturated; WBCKillNN values represent the maximal kill rate induced by granulocytes in the normal cohort; WBCKillNN₅₀ values represent the organism load at which the system is half saturated. In the Bayesian estimates, the WBCKillN and WBCKillNN give the estimated killing rates for the granulocytes alone (no-treatment control) or for the granulocyte killing effect plus the tedizolid killing effect (treated cohorts). The pharmacokinetic parameter values for TR-701 and TR-700 were fixed at values identified previously (2). K_a = 66.4; K_hydrol = 1.48; CL₇₀₁ = 0.0102; V₇₀₁ = 0.384; CL₇₀₀ = 0.0101; V₇₀₀ = 0.0164; K₃₄ = 12.7; K₄₃ = 12.8.