Table 1.
Parameter | Unit of measurement | Mean | Median | SD |
---|---|---|---|---|
Kg | h−1 | 1.300 | 0.884 | 0.879 |
Popmax | CFU/g | 1.36 × 109 | 1.72 × 109 | 6.48 × 108 |
Kk-max | h−1 | 1.782 | 0.104 | 2.768 |
C50k | mg/liter | 3.860 | 4.513 | 1.848 |
Hk | Unitless | 8.056 | 7.895 | 0.431 |
WBCKillN | (CFU/g)/h | 0.657 | 0.536 | 0.557 |
WBCKillN50 | CFU/g | 3.47 × 106 | 2.41 × 106 | 3.02 × 106 |
WBCKillNN | (CFU/g)/h | 2.638 | 0.995 | 3.797 |
WBCKillNN50 | CFU/g | 1.58 × 106 | 1.80 × 104 | 3.22 × 106 |
Kg values represent the first-order growth rate constant; Popmax values represent the estimated maximal number of organisms in stationary phase; Kk-max values represent the first-order kill rate constant directly induced by tedizolid; C50k values represent the tedizolid concentration at which kill rate is half maximal; Hk values represent the Hill constant; WBCKillN values represent the maximal kill rate induced by granulocytes in the granulocytopenic cohort; WBCKillN50 values represent the organism load at which the system is half saturated; WBCKillNN values represent the maximal kill rate induced by granulocytes in the normal cohort; WBCKillNN50 values represent the organism load at which the system is half saturated. In the Bayesian estimates, the WBCKillN and WBCKillNN give the estimated killing rates for the granulocytes alone (no-treatment control) or for the granulocyte killing effect plus the tedizolid killing effect (treated cohorts). The pharmacokinetic parameter values for TR-701 and TR-700 were fixed at values identified previously (2). Ka = 66.4; Khydrol = 1.48; CL701 = 0.0102; V701 = 0.384; CL700 = 0.0101; V700 = 0.0164; K34 = 12.7; K43 = 12.8.