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Pyrazinoic acid decreases cellular ATP levels. M. bovis BCG was grown in liquid culture (pH = 6.5) as described by Haagsma et al. (9). Cellular ATP levels in the presence of pyrazinoic acid or pyrazinamide were determined at the indicated time points using the luciferase bioluminescent method (17), based on cell volumes determined as described by Rao et al. (25). Bars represent the mean values and standard deviations of the results of three independent experiments.
