Table 1.

Moxidectin plasma and breast milk PK results

Parametera	Value (mean ± SD)b
Cmax (ng/ml)	87 ± 25
tmax (h)	4.18 ± 1.59
AUC (ng·h/ml)	4,046 ± 1,796
λz (h−1)	0.00093 ± 0.00029
t1/2 (h)	832 ± 321
CL/F (liters/h)	2.349 ± 1.067
Vλz/F (liters)	2,526 ± 772
% dose excreted in milk	0.701 ± 0.299
Amt excreted in milk (mg)	0.056 ± 0.024
CLmilk (liters/h)	0.016 ± 0.009
AUCmilk/AUC	1.77 ± 0.66
Absolute infant dose (mg)	0.056 ± 0.024
Relative infant dose (%)	8.73 ± 3.17

^aAUC, total area under the concentration-time curve; AUC_milk, AUC for moxidectin in breast milk; C_max, peak plasma concentration; CL/F, apparent oral dose clearance; CL_milk, clearance in milk; t_½, terminal phase elimination half-life;, t_max, time to C_max; V_z/F, apparent volume of distribution; λ_z, terminal-phase elimination rate constant.

^bn = 12.