Table 2.
Pharmacokinetic parameters of cefazolin in plasma (total and unbound) and ISF of subcutaneous adipose tissue
| Pharmacokinetic parametera | Median value (IQR) |
||
|---|---|---|---|
| Total plasma | Unbound plasma | Unbound ISF | |
| Cmax (mg/liter) | 404 (289–458) | 25.7 (21.6–27.6) | 23.7 (17.2–27.1) |
| Tmax (h) | 0.08 (0.08–0.09) | 0.08 (0.08–0.09) | 2.0 (1.5–3.0) |
| Cmin (mg/liter) | 35.7 (30.4–54.3) | 5.7 (5.4–8.1) | 6.7 (6.0–6.9) |
| t1/2 (h) | 2.7 (2.4–4.1) | ||
| AUMC0-last (mg-h/liter) | 53,486 (39,116–72,613) | 11,444 (6,650–16,165) | 8,675 (7,530–11,942) |
| AUMC0-∞ (mg-h/liter) | 178,899 (103,300–392,810) | 535,767 (304,118–641,091) | 1,484,890 (485,872–2,255,884) |
| AUC0-last (mg-h/liter) | 452 (420–542) | 77.6 (59.0–82.4) | 65.6 (51.7–83.5) |
| AUC0-∞ (mg-h/liter) | 670 (518–1,113) | 382 (295–420) | 2,044 (994–3,857) |
| MRT (h) | 259 (210–347) | 1,402 (1,030–1,525) | 147 (125–178) |
| kel (h) | 0.26 (0.17–0.28) | 0.04 (0.04–0.06) | 0.22 (0.18–0.32) |
| CLtotal (liters/h) | 3.01 (1.73–3.94) | ||
| Vz (liters) | 11.6 (10.2–14.1) | 119.3 (115.2–123.3) | |
| Vz (liters/kg) | 0.14 (0.11–0.15) | 1.31 (1.25–1.40) | |
| fAUCISF tissue /AUCplasmab | 0.15 (0.12–0.19) | ||
| fAUCISF tissue /fAUCplasmab | 0.85 (0.78–1.06) | ||
Cmax, observed maximum concentration; Tmax, time that Cmax was observed; Cmin, observed minimum concentration; t1/2, elimination half-life; AUMC0-last, area under the moment curve from 0 h to the last measurement at the completion of surgery; AUMC0-∞, area under the moment curve from 0 h to infinity; AUC0-last, area under the concentration-time curve from 0 h to the last measurement at the completion of surgery; AUC0-∞, area under the concentration-time curve from 0 h to infinity; MRT, mean residence time; kel, elimination rate constant; CLtotal, total clearance; Vz, apparent volume of distribution during terminal phase; fAUCISF tissue, unbound AUC in interstitial fluid of subcutaneous tissue; AUCplasma, AUC in plasma, obtained using total concentrations; fAUCplasma, AUC in plasma, obtained using unbound concentrations.
Calculated using AUC0-last.