Table 1.
Antiviral activity of ODE-HPMP nucleosides and ODE-MPMPA in HIV-1-infected MT-2 cellsa
| Compound | Mean EC50 (nM) ± SD | Mean CC50 (nM) ± SD | Selectivity indexb |
|---|---|---|---|
| Reference compounds | |||
| Adefovir | 1,300 ± 700 (7) | 157,000 ± 54,000 (3) | 121 |
| Tenofovir | 680 ± 460 (6) | >100,000 (7) | >147 |
| 3′-Hydroxyl compounds | |||
| ODE-(S)-HPMPA | 0.1 ± 0.1 (6) | 30 ± 20 (3) | 300 |
| ODE-(S)-HPMPC | 0.1 ± 0.1 (4) | 20 ± 3 (3) | 200 |
| ODE-(S)-HPMPDAP | 1.0 ± 2.0 (3) | 1,900 ± 800 (3) | 1,900 |
| ODE-(S)-HPMPG | 9.0 ± 6.0 (3) | 240 ± 30 (3) | 27 |
| ODE-(S)-HPMPT | >10,000 (3) | 25,000 (3) | <2.5 |
| 3-Methoxy compound | |||
| ODE-(S)-MPMPA | 30 ± 15 (3) | 15,000 ± 3,100 (3) | 500 |
a
Values in parentheses represent the numbers of independent experiments.
b
Selectivity index values were determined as follows: mean CC50/mean EC50.