Table 2.

Pairwise analyses of histopathological changes in the distal colons of mice^a

	Control vs CR				Control vs CTC+CR				CR vs CTC+CR
Cat/Day	3	8	14	21	3	8	14	21	3	8	14	21
EHb	0.317	0.034*	0.076	0.090	1.000	0.025*	0.075	0.456	0.317	0.317	0.261	0.197
CH	0.317	0.025*	0.076	0.034*	0.317	0.039*	0.068	0.114	1.000	0.317	0.486	0.796
II	1.000	0.046*	0.068	0.037*	1.000	0.043*	0.068	0.121	1.000	0.637	0.814	0.261
EI	1.000	0.034*	0.068	0.114	1.000	0.025*	0.197	0.317	1.000	0.317	0.816	0.456
MA	1.000	0.043*	0.045*	0.025*	0.317	0.043*	0.068	0.034*	0.317	0.456	0.317	0.317
GC	1.000	0.034*	0.068	0.317	1.000	0.034*	0.182	1.000	1.000	1.000	0.796	0.317
Total	0.114	0.046*	0.037*	0.046*	0.114	0.046*	0.037*	0.072	1.000	0.261	1.000	0.513

^aPairwise comparisons were conducted using the Kruskal Wallis non-parametric test. P values marked with an asterisk are significantly different (P = 0.05).

^bPathology categories (Cat): EH, epithelial hyperplasia; CH, crypt height; EI, epithelial injury; II, inflammatory infiltrates; MA, mitotic activity; GC, globlet cell depletion. Total score corresponds to the sum of scores of all categories.