Figure 1.

Schematic structure of the APC/C. The APC/C is divided in three parts: the structural complex composed of three subunits (in pink), the TPR arm made of nine proteins (in blue) and a second arm (the catalytic arm) made of three proteins (in green) interacting with the E2 protein (in purple) and the substrate (in grey). The activity and specificity of the APC/C is modulated by various adaptor/co-activators (in orange). The location of Apc14 (in black) remains uncertain. The presence of RING finger and Cullin conserved functional domains, and of TPR and WD repeats is indicated.