Table 1.

Whole brain concentrations of KYNA or 7-Cl-KYNA in rats pretreated with kynurenine (i.p., 1.5 h, n = 14) or 4-Cl-KYN (i.p., 1.5 h, n = 10–15).¹

Treatment	KYNA, nM	7-Cl-Kyna, nM
Control2	23.26 ± 2.67	-
Kynurenine, 200 mg/kg	123.10 ± 18.76***	-
4-Cl-Kynurenine, 25 mg/kg	–	9.23 ± 1.60
4-Cl-Kynurenine, 50 mg/kg	–	18.44 ± 3.14
4-Cl-Kynurenine, 100 mg/kg	–	52.10 ± 8.84

¹Values represent mean ± SEM. Statistics:

^***p < 0.001 vs. control (Mann-Whitney U-test).

²n = 13.