Table 3.
Inhibitory effects of selected copper complexes.
| Complex | Biological in vitro activity | IC50 a,b (μΜ) | Reference | |
|---|---|---|---|---|
| Bis(4-nitroacetophenone thiosemicarbazonat) copper(II) | Anti-trypanosomal | Trypanosoma cruzi | 0.056 c (0.28)c | [63] |
| Bis(5-nitrofuran-2-carboxaldehyde-N4-ethylpiperidine thiosemicarbazone) copper(II) chloride | Antiamoebic | HK-9 strain of Entamoeba histolytica | 0.34(2.68) | [62] |
| Bis(thiophene-2-carboxaldehyde-N4-methyl benzyl thiosemicarbazone) copper(II) chloride | Antiamoebic | HK-9 strain of Entamoeba histolytica | 0.21(1.21) | [62] |
| (2-acetylpyridine)pyridine-2-carboxamidrazone copper(II) chloride | Antiproliferative | Mouse melanoma cell line B16F10. d | 6.8 | [60] |
| Cu2(μ-L)2(μ-Cl)2L2Cl2L= 6-(2-chlorobenzylamino) purine | Antitumor | Mouse melanoma B16FO | 8.2(85) | [61] |
| Human malignant melanoma G361 | 20.0 | [61] | ||
| (95) | ||||
| Human osteogenic sarcoma HOS | 23 (>100) | [61] | ||
| Human breast adenocarcinoma MCF7 | 24(>100) | [61] | ||
| Tetra(N-methyl-1,3,5-triaza-7-phosphaadamantane copper(I) tetrafluoro borate | Antitumor | Cervix tumor (HeLa) | 7.6 | [69] |
| Colon tumor (HCT-15) | 19.2 | [69] | ||
| Lung tumor (A549) | 8.5 | [69] | ||
| Melanoma (A375) | 16.4 | [69] | ||
| Bis(triphenylphosphine), dihydridobis(3-nitro-1,2,4-triazolyl)borate copper(I) | Antitumor | Promyelocytic leukemia (HL60) | 4.8 | [79] |
| Cervix carcinoma (A431) | 6.7 | [69] | ||
| Lung tumor (A549) | 1.5 | [69] | ||
| Melanoma (A375) | 16.4 | [69] | ||
aValues refer to the most active copper (II) complex tested. Half- maximal inhibitory concentration (IC50) is a quantitative measure of the effectiveness of a compound in inhibiting a biological function as it indicates how much of a particular substance is needed to inhibit a given biological process.
bValues in parenthesis refer to the free ligand.
cThese values refer to inhibitory dose (ID50): dose that inhibits 50% of Trypanosoma cruzi growth.
dThe exponentially growing cells were counted by haemocytometer using the Trypan blue exclusion method to quantify cell viability.