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IC50 Values of Paclitaxel Conjugatesa
| H2009 Cells | H460.1 | |
|---|---|---|
| Paclitaxel | 14.8 ± 3.3 nM | 23.6 ± 7.4 nM |
| H2009.1-Paclitaxel | 460 ± 75 nM | Not Reachedb |
| Scramble H2009.1-Paclitaxel | Not Reachedb | Not Reachedb |
Cells were exposed to drug for 10 min followed by a 120 h recovery in media. The short incubation time assures that cytotoxicity is due to the peptide conjugate and not free pacliatxel released prematuraly from the conjugate.
Not reached at highest concentration used, 1 μM.
