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Yohimbine enhancement of cue-induced reinstatement in female rats across the estrous cycle. Active (top) and inactive (bottom) lever responding (mean ± SEM) are shown for the three estrous cycle phases (estrus, diestrus I/II, proestrus) following vehicle or yohimbine injection prior to the “No Cue” or “Cue” reinstatement tests (ns=9-22). Significant differences are indicated for vehicle vs. yohimbine injection (*p<0.05) and for the “Cue” vs. “No Cue” presentation (†p< 0.05).
