Figure 7. Blockade of the Cxcl-Cxcr2 axis shows an antitumor effect by reducing tumor angiogenesis on the Kras+Tgfbr2^KO PDAC mice.

(A) H&E staining of the Kras+Tgfbr2^KO PDAC mouse treated with vehicle, repertaxin, gemcitabine, repertaxin plus gemcitabine, or SB225002. Scale bars: 400 μm (insets, 100 μm). Tumor size index in each treatment group was quantified (n = 6). (B) Immunohistochemistry of von Willebrand factor. Scale bars: 100 μm. MVD in each treatment group was quantified (n = 4). *P < 0.05 vs. control.