Skip to main content
. 2011 Sep 19;121(10):3846–3859. doi: 10.1172/JCI44952

Figure 7. Nonhematopoietic stromal cell–derived IL-6 induces vascular ICAM-1 expression in the tumor microenvironment.

Figure 7

(A) IL-6 concentration in B16 tumor lysates from NT control or STT-treated WT and Il6–/– mice, determined by Luminex. Data are from at least 3 mice. n.d., not detected. P = 0.53, NT versus STT in WT mice. (B) Immunofluorescence staining of ICAM-1 (red) and CD31 (green) in WT and Il6–/– mice implanted with B16 tumors. Numbers denote MFI for CD31+ vessels. Scale bar: 100 μm. (C) Quantification of endogenous CD8+ T cells in B16 tumors. Data are from individual mice and are representative of at least 3 independent experiments. *P < 0.0001 versus NT. (D) Quantitative image analysis for ICAM-1 and CD31 staining of B16 tumor vessels in bone marrow chimeric mice. Numbers denote MFI for CD31+ vessels.