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. 2011 Sep 1;121(10):3991–4002. doi: 10.1172/JCI45563

Figure 2. Dramatically elevated serum IgA in BAFF-Tg mice correlating with serum BAFF levels.

Figure 2

Autoreactivity is limited to the IgM isotype. (A) Serum IgM, IgG, and IgA levels in a cohort of BAFF-1 Tg mice and BAFF-2 Tg mice at 3 to 4 months of age compared with those of matched WT controls. (B) Serum levels of IgA, but not IgM or IgG, are correlated with serum BAFF levels, as measured by ELISA in the BAFF-2 female cohort in A. (C) Antinuclear autoreactivity is observed only in the IgM isotype in BAFF-1 Tg mice. Antichromatin and (D) anti-dsDNA antibodies were evaluated in male BAFF-1 Tg mice and C57BL/6 mice (both 6 months old). Open circles show serum autoantibody levels from a diseased 3-month-old MRL/lpr mouse for reference. Individual symbols represent individual mice; horizontal bars represent the mean ± SEM. F, female; M, male.