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. 2011 Sep 1;121(10):3860–3871. doi: 10.1172/JCI45963

Figure 5. CHS effector CD8+ T cells exhibit enhanced expression of p75, which increases their susceptibility to TNF-mediated apoptosis in LZT.

Figure 5

(A) Percentage of p75+CD8+ T cells in sensitized (black bar) and solvent-treated (gray bar) mice as assessed by flow cytometry (pooled data of 6 independent experiments). (B) Percentage of p75+CD8+ T cells in tolerized (white bars) and mock-tolerized (solvent-treated; black bars) Thy1.1+ recipient mice (5 per group) that were adoptively transferred with T cells isolated from sensitized Thy1.2+ mice and then challenged to induce CHS. Gates were set on recipients’ Thy1.1+ cells or Thy1.2+ T cells (derived from the sensitized donor mice). Pooled data from 4 independent experiments (left panel) and data from 1 representative experiment (right panel) are shown. Data are shown as mean ± SD. *P < 0.05; **P < 0.01.