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. 2011 Sep 1;121(10):3954–3964. doi: 10.1172/JCI57362

Figure 5. Maintenance but not early generation of virus-specific ASCs is impaired in TACI–/– mice.

Figure 5

(A) MedLNs from WT and TACI–/– mice (n = 10–14 mice/group) were harvested 6–8 days p.i. and assayed for PR8-specific IgM, IgG, and IgA ASCs by ELISPOT. (B) PR8-specific IgG and IgA ASCs from indicated organs of WT and TACI–/– mice were determined by ELISPOT at days 32–34 p.i. (n = 5–8 mice/group). (C) WT and TACI–/– mice (n = 5 mice/group) received 1,000 HAU/100 μl purified PR8 virus intravenously, and PR8-specific IgG ASCs were enumerated 30 days later in BM and spleen. Data with mean ± SEM are representative of at least 2 independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001.