Figure 5. Aβ deposition is enhanced in the walls of brain microvessels in APP_dt×Abcc1^–/– mice.

The graphs present the proportion of meningeal vessel walls that were affected by different degrees of Aβ deposition (Aβ-positive circumference). Assessment of APP_dt mice deficient in ABCG2 or ABCB1, respectively, revealed no differences in CAA relative to APP_dt controls. In contrast, 53% of blood vessels were severely affected by CAA (>75% of the circumference is decorated with Aβ) in APP_dt×Abcc1^–/– mice versus 23% in APP_dt controls. n = 3.