. Author manuscript; available in PMC: 2012 Nov 18.

Published in final edited form as: Toxicology. 2011 Aug 16;289(2-3):141–150. doi: 10.1016/j.tox.2011.08.009

Table 3.

Coagulation Parameters in Rats Exposed to CP-31398 for 28 Days

Group	Sex	Dose (mg/kg/day)	Prothrombin Time (seconds)	Activated Partial Thromboplastin Time (seconds)	Fibrinogen (mg/dL)
1	Male	0	17.8 ± 1.2	18.4 ± 1.6	302 ± 27
2	Male	40	17.0 ± 0.8	17.3 ± 0.9	315 ± 22
3	Male	80	16.8 ± 0.7	19.1 ± 3.0	306 ± 28
4	Male	160	21.1 ± 2.0^*	40.5 ± 10.4^*	457 ± 56^*
1	Female	0	16.9 ± 0.5	15.1 ± 1.1	273 ± 35
2	Female	40	16.8 ± 0.8	15.1 ± 1.8	248 ± 22
3	Female	80	18.8 ± 1.4^*	23.9 ± 6.1^*	254 ± 84
4	Female	160	19.3 ± 1.2^*	34.2 ± 8.1^*	394 ± 33^*

p < 0.05 versus sex-matched vehicle controls