Table 4.

Selected Organ Weights in Rats Exposed to CP-31398 for 28 Days

Group	Sex	Dose (mg/kg/day)	Liver Weights		Lung Weights		Adrenal Weights
			Absolute (g)	Relative (% of Body Weight)	Absolute (g)	Relative (%of Body Weight)	Absolute (g)	Relative (%of Body Weight)
1	Male	0	11.7 ± 1.7	3.05 ± 0.38	1.58 ± 0.22	0.41 ± 0.05	0.074 ± 0.033	0.019 ± 0.009
2	Male	40	10.9 ± 1.3	3.02 ± 0.24	1.69 ± 0.29	0.47 ± 0.06	0.095 ± 0.034	0.026 ± 0.009
3	Male	80	12.7 ± 2.0	3.48 ± 0.36	2.06 ± 0.21	0.58 ± 0.07	0.100 ± 0.023	0.028 ± 0.007
4	Male	160	28.6 ± 4.4*	10.97 ± 1.12*	2.43 ± 0.19*	0.94 ± 0.13*	0.199 ± 0.052*	0.076 ± 0.018*
1	Female	0	7.4 ± 0.6	3.00 ± 0.19	1.26 ± 0.15	0.51 ± 0.06	0.076 ± 0.015	0.031 ± 0.006
2	Female	40	7.5 ± 0.8	3.22 ± 0.26	1.26 ± 0.12	0.54 ± 0.05	0.078 ± 0.018	0.034 ± 0.007
3	Female	80	9.6 ± 1.1*	4.37 ± 0.76*	1.52 ± 0.14	0.69 ± 0.08	0.093 ± 0.012	0.042 ± 0.007*
4	Female	160	23.5 ± 5.3*	11.23 ± 2.77*	2.00 ± 0.25	0.95 ± 0.12*	0.172 ± 0.034*	0.082 ± 0.017*

^*p < 0.05 versus sex-matched vehicle controls