Table 7.
Group | Sex | CP-31398 Dose (mg/kg/day) | Left Kidney Weights | Heart Weights | Liver Weights | |||
---|---|---|---|---|---|---|---|---|
Absolute (g) | Relative (% of Body Wt) | Absolute (g) | Relative (% of Body Wt) | Absolute (g) | Relative (% of Body Wt) | |||
1 | M | 0 | 22.3 ± 4.3 | 0.24 ± 0.03 | 70.2 ± 4.1 | 0.76 ± 0.04 | 270.4 ± 32.6 | 2.92 ± 0.28 |
2 | M | 10 | 23.1 ± 3.6 | 0.26 ± 0.05 | 63.9 ± 5.7 | 0.72 ± 0.05 | 269.9 ± 43.1 | 3.04 ± 0.49 |
3 | M | 20 | 22.4 ± 6.8 | 0.25 ± 0.05 | 68.1 ± 13.3 | 0.77 ± 0.05 | 278.9 ± 58.0 | 3.15 ± 0.23 |
4 | M | 40 | 23.4 ± 3.2 | 0.27 ± 0.01 | 67.1 ± 5.3 | 0.76 ± 0.04 | 298.9 ± 55.9 | 3.37 ± 0.26 |
1 | F | 0 | 23.9 ± 1.3 | 0.27 ± 0.03 | 74.2 ± 2.1 | 0.84 ± 0.07 | 261.6 ± 21.2 | 2.96 ± 0.32 |
2 | F | 10 | 19.8 ± 1.5* | 0.26 ± 0.02 | 60.0 ± 5.3* | 0.77 ± 0.09 | 223.7 ± 25.5 | 2.88 ± 0.21 |
3 | F | 20 | 21.4 ± 0.7 | 0.28 ± 0.02 | 60.3 ± 2.0* | 0.78 ± 0.10 | 248.6 ± 11.3 | 3.21 ± 0.01 |
4 | F | 40 | 18.7 (n = 1) | 0.25 | 52.4 (n=1) | 0.71 | 209.3 (n=1) | 2.85 |
p < 0.05 versus sex-matched vehicle controls