. Author manuscript; available in PMC: 2012 Nov 18.

Published in final edited form as: Toxicology. 2011 Aug 16;289(2-3):141–150. doi: 10.1016/j.tox.2011.08.009

Table 7.

Selected Day 29 Organ Weights in Dogs Receiving CP-31398 for 28 Days

Group	Sex	CP-31398 Dose (mg/kg/day)	Left Kidney Weights		Heart Weights		Liver Weights
Group	Sex	CP-31398 Dose (mg/kg/day)	Absolute (g)	Relative (% of Body Wt)	Absolute (g)	Relative (% of Body Wt)	Absolute (g)	Relative (% of Body Wt)
1	M	0	22.3 ± 4.3	0.24 ± 0.03	70.2 ± 4.1	0.76 ± 0.04	270.4 ± 32.6	2.92 ± 0.28
2	M	10	23.1 ± 3.6	0.26 ± 0.05	63.9 ± 5.7	0.72 ± 0.05	269.9 ± 43.1	3.04 ± 0.49
3	M	20	22.4 ± 6.8	0.25 ± 0.05	68.1 ± 13.3	0.77 ± 0.05	278.9 ± 58.0	3.15 ± 0.23
4	M	40	23.4 ± 3.2	0.27 ± 0.01	67.1 ± 5.3	0.76 ± 0.04	298.9 ± 55.9	3.37 ± 0.26
1	F	0	23.9 ± 1.3	0.27 ± 0.03	74.2 ± 2.1	0.84 ± 0.07	261.6 ± 21.2	2.96 ± 0.32
2	F	10	19.8 ± 1.5^*	0.26 ± 0.02	60.0 ± 5.3^*	0.77 ± 0.09	223.7 ± 25.5	2.88 ± 0.21
3	F	20	21.4 ± 0.7	0.28 ± 0.02	60.3 ± 2.0^*	0.78 ± 0.10	248.6 ± 11.3	3.21 ± 0.01
4	F	40	18.7 (n = 1)	0.25	52.4 (n=1)	0.71	209.3 (n=1)	2.85

p < 0.05 versus sex-matched vehicle controls