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. Author manuscript; available in PMC: 2011 Oct 17.
Published in final edited form as: J Cogn Neurosci. 2010 Nov;22(11):2530–2540. doi: 10.1162/jocn.2009.21375

Figure 6.

Figure 6

STP has a GluR1-dependent component. STP was diminished in the adult GluR1 KO mouse relative to WT. (A) Response to STP induction paradigm at time 0 in adult WT mice (filled squares, n = 8), ages P40–62 and GluR1 KO mice (open squares, n = 7), ages P40–62. At time 40 LTP was induced using a theta-burst induction protocol. (B) Data from A showing STP on an expanded scale, with solid lines indicating double exponential fits to the data. In the GluR1 KO, the amplitude of the fast component was 27% of the WT [105 ± 1.5% (n = 7), as compared to 120 ± 4.6% in the WT (n = 8); note, numbers in this section are fit parameters ± 95% confidence intervals]. The contribution of the fast component to STP was further reduced because it displayed a more rapid decay (0.56 ± 0.3 vs. 1.9 ± 0.48 min in the WT). The slow component was very small and not substantially changed in the KO. (C) Response to STP induction paradigm at time 0 in adult GluR1 KO mice (open squares, n = 7), ages P40–62 and juvenile GluR1 KO mice (gray squares, n = 6), ages P22–25. At 40 min, LTP was induced using a theta-burst induction protocol.